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Generally, thermalization issues will be discovered during the
pre-cool. Because the cool down time depends on
at lower temperatures), the time to cool a poorly
thermalized mass from 300K-10K will be much longer than from 10K-10mK.
However, if you do not monitor the temperature of the poorly
thermalized mass, what you may find is that the system seems to
get cold, but then fails to reach base. This may be because the poorly
thermalized mass is still
K and is warming the rest of the system.
In either case, you will need to thermalize the cold mass better.